- Author: Doo Sun SIM , Myung Ho JEONG , Ho Chun SONG , Jahae KIM , Hee Seung BOM , In Seok JEONG , Sang Gi OH , Sang Hyung KIM , Dae Sung PARK , Jung Ha KIM , Kyung Seob LIM , Min Suk KIM , Shi Hyun RYU , Hyun Kuk KIM , Sung Soo KIM , Su Young JANG , Jae Yeong CHO , Hae Chang JEONG , Ki Hong LEE , Keun Ho PARK , Nam Sik YOON , Hyun Ju YOON , Kye Hun KIM , Young Joon HONG , Hyung Wook PARK , Ju Han KIM , Youngkeun AHN , Jeong Gwan CHO , Jong Chun PARK , Jung Chaee KANG
- Date: 2014/12/23
- Journal: 2014/12/23
- PMID: 25552881
- PMCID: PMC4278025
- DOI: 10.3346/jkms.2015.30.1.34
Abstract
Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10), group 2 (no angiotensin-converting enzyme inhibitor [ACEI] or ARB, n=10), group 3 (perindopril 2 mg daily, n=10), group 4 (valsartan 40 mg daily, n=10), or group 5 (fimasartan 30 mg daily, n=10). Acute MI was induced by occlusion of the left anterior descending artery for 50 min. Echocardiography, single photon emission computed tomography (SPECT), and F-18 fluorodeoxyglucose cardiac positron emission tomography (PET) were performed at baseline, 1 week, and 4 weeks. Iodine-123 meta-iodobenzylguanidine (MIBG) scan was done at 6 weeks for visualization of cardiac sympathetic activity. Left ventricular function and volumes at 4 weeks were similar between the 5 groups. No difference was observed in groups 2 to 5 in SPECT perfusion defect, matched and mismatched segments between SPECT and PET at 1 week and 4 weeks. MIBG scan showed similar uptake between the 5 groups. Pathologic analysis showed similar infarct size in groups 2 to 5. Infarct size reduction was not observed with use of fimasartan as well as other ACEI and ARB in a porcine model of acute MI.
Keywords: Angiotensin Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Myocardial Infarction.