- Author: HJ Cho, M Qayumov, DW Kim, IS Jeong
- Date: 2018/06/01
- Journal: Pediatric Critical Care Medicine;19(6S);246-247
- PMID:
- PMCID:
- DOI: 10.1097/01.pcc.0000538097.52610.da
Abstract
Aims & Objectives:
Several CPB models in the small animals have already been introduced with various techniques. We describe a veno-venous(VV) extracorporeal circulation (ECC) model in rat allowing a sufficient blood flow with satisfactory perioperative results.
Methods
10 rats underwent VV type ECC with perfusion cannula of 24Fr. Angiocatheter and drainage cannula of neonatal feeding tube to jugular veins. We classified these rats into two groups according to priming solution: Saline group (N=5) and Albumin group (N=5)
Results
Mean body weight was 538.7 ± 42.4 g. Post-CPB potassium level was significantly different between 2 groups (7.6 ± 2.5 versus 5.8 ± 0.3, p=0.006). Three rats survived after 120minutes CPB times in albumin group.
Conclusions
Adding albumin to priming solution makes more satisfactory results in rat ECMO model. Further investigation will be needed.