- Author: Hwa Jin Cho, Mukhammad Kayumov, Seunghwan Song, Yang Hyun Cho, In-Seok Jeong
- Date: 2024/09/01
- Journal: ASAIO Journal;70(supplement4);56
- PMID:
- PMCID:
- DOI: 10.1097/01.mat.0001070124.43919.ac
Abstract
Background: Patients on extracorporeal membrane oxygenation (ECMO) often require infusions of opioids and/or sedative-hypnotics (eg benzodiazepines) for analgesia and sedation which causes iatrogenic dependence and delirium. This study describes our experience using an interdisciplinary collaboration implementing the protocolized use of phenobarbital, guanfacine and buprenorphine to reduce sedation/analgesia requirements and optimize sedation. Methods: We performed a single-center retrospective process improvement chart review of ECMO patients before and after the implementation of our protocol. All patients post-intervention received phenobarbital loading and maintenance, underwent a buprenorphine micro-induction, and received scheduled guanfacine. Data elicited for comparison included RASS score ranges, daily benzodiazepine and opioid use (non-buprenorphine, in morphine …