- Author: Sainath Raman, Kristen S Gibbons, Muralidharan Jayashree, AV Lalitha, Rinaldo Bellomo, Robin Blythe, David Buckley, Warwick Butt, Hwa Jin Cho, Michele Cree, Daniela C de Souza, Simon Erickson, Marino Festa, Subodh Ganu, Shane George, Ebor Jacob James, Kerry Johnson, Renate Le Marsney, Paula Lister, Trang MT Pham, Puneet Singh, Balasubramanian Venkatesh, Renee Wall, Debbie A Long, Luregn J Schlapbach
- Date: 2024/12/26
- Journal: Pediatric Critical care Medicine10.1097
- PMID: 39724024
- PMCID: PMC11878590
- DOI: 10.1097/PCC.0000000000003674
Abstract
OBJECTIVES: Pediatric sepsis results in significant morbidity and mortality worldwide. There is an urgent need to investigate adjunctive therapies that can be administered early. We hypothesize that using vitamin C combined with hydrocortisone increases survival free of inotropes/vasopressors support until day 7 compared with standard care. Here we describe the Resuscitation in Paediatric Septic Shock using Vitamin C and Hydrocortisone (RESPOND) trial protocol, which aims to address this hypothesis. DESIGN: Randomized, open label, controlled, parallel-group, three-arm trial with integrated economic evaluation. SETTING: Nine Australia and New Zealand PICUs, with interest from additional international sites. PATIENTS: Children between 7 days and younger than 18 years old who are treated for suspected or confirmed sepsis and receiving inotropes/vasopressors for greater than 1 hour. INTERVENTIONS: IV …